Time: 2025年11月19日 下午15:30
Venue: 创新港3号巨构2011会议室3-2011
Invite Speaker：Prof. Agnieszka Szumna
【Title】Old Macrocycles, New Tricks: Resorcinarenes in Peptide Cage Construction and Supramolecular Umpolung
Abstract：Resorcinarenes are classic, readily available macrocycles in supramolecular chemistry. Beyond their traditional role as hosts, their structural versatility enables modern applications. This lecture will highlight non-traditional uses of these macrocycles in several areas:
1. Construction of Chiral Peptide-Based Capsules via dynamic covalent chemistry and self-assembly.
2. Mechanochemical Induction of Complexation-using mechanical force (e.g., grinding) to drive host-guest binding.
3. Large-Stokes-Shift Fluorescent Cation Receptors based on dual Excited-State Intramolecular Proton Transfer (ESIPT).
4. CH-Bonding Anion Receptors through supramolecular umpolung, utilizing weakly acidic C–H bonds for anion recognition.
Introduction：Prof. Szumna earned her Ph.D. with distinction in the field of crystallography from the Institute of Organic Chemistry, PAS, and completed a postdoctoral stay at the University of Missouri, Columbia, USA, working with Prof. Jerry L. Atwood. Then she started her independent career at the Institute of Organic Chemistry. She successfully completed her Habilitation in 2010, which was recognized with the Prime Minister Award for outstanding achievement. She was subsequently granted the title of Full Professor by the President of the Republic of Poland in 2019. She now leads a research group dedicated to molecular recognition, self-assembly, and the design of novel systems, including peptide-based capsules and advanced receptors. Her expertise in the field is underscored by her extensive publication record (over 70 papers) and her recognition with the Marie Skłodowska-Curie-Wilhelm Klemm-Vorlesung Lectureship awarded jointly by Polish and German Chemical Societies (2017).
